Monocytes and neutrophils in the inflammatory cascade of systemic onset Juvenile Idiopathic Arthritis
نویسندگان
چکیده
Background Systemic onset Juvenile Idiopathic Artritis (sJIA), also known as Still’s disease, is characterized by arthritis with symptoms of systemic inflammation such as spiking fever, rash and serositis. It is considered an autoinflammatory disease with a major role for the innate immune system, reflected by extremely high serum levels of S100 proteins and interleukin (IL)-18. How the number of monocytes and neutrophils relate to the increased levels of S100-proteins and IL-18 and to sJIA disease progression is still unknown.
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